ANTICANCER EFFECT OF 1,2,3-TRIAZOLE-CONTAINING COMPOUNDS.
Keywords:
melampomagnolide B-triazole, apoptosis, transwell assay, 1,2,3-triazoles, epithelial proteins, snail, zonula occludens-1 (ZO-1), E-cadherinAbstract
Natural compounds and derivatives of natural compounds containing 1,2,3-Triazole are widely used in cancer treatment in combination therapy. Although the 1,2,3-triazole moiety does not occur in nature, the production of "1,2,3-triazole-natural compound" hybrids has become active in medicinal chemistry and has attracted interest as an anticancer candidate.
References
Bozorov, K., Zhao, J., & Aisa, H. A. (2019). 1, 2, 3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview. Bioorganic & medicinal chemistry, 27(16), 3511-3531.
Totobenazara J, Burke AJ. New click-chemistry methods for 1,2,3-triazoles synthesis: recent advances and applications. Tetrahedron Lett. 2015;56:2853–2859
Shashank, A. B., Karthik, S., Madhavachary, R., & Ramachary, D. B. (2014). An Enolate-Mediated Organocatalytic Azide-Ketone [3+2]-Cycloaddition Reaction: Regioselective High-Yielding Synthesis of Fully Decorated 1,2,3-Triazoles. Chemistry - A European Journal, 20(51), 16877–16881.
Huisgen, R. in 1,3-dipolar cycloaddition chemistry, Wiley, New
York, 1984,pp.1-176.
Ding Y, Guo H, Ge W, et al. Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities. . Eur J Med Chem. 2018;156:216–229.
Janganati V, Ponder J, Balasubramaniam M, et al. MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells. Eur J Med Chem. 2018;157:562–581.
Yu H, Hou Z, Tian Y, Mou Y, Guo C. Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents. Eur J Med Chem. 2018;151:434–449
Ke Y, Liang J-J, Hou R-J, et al. Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents. Eur J Med Chem. 2018;157:1249–1263.
Ke Y, Wang W, Zhao L-F, et al. Design, synthesis and biological mechanisms reearch on 1,2,3-triazole derivatives of Jiyuan Oridonin A. . bior Med Chem.
;26:4761–4773.
Wei G, Sun J, Hou Z, et al. Novel antitumor compound optimized from natural
saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a
p53 activator through the mitochondrial pathway. . Eur J Med hem.2018;157:759–772.
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